Difference between revisions of "Moclobemide-escitalopram"
From Psychiatrienet
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| − | + | {{Drugswitch | |
| + | | from = moclobemide | ||
| + | | to = escitalopram | ||
| + | | stop = | ||
| + | * '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day. | ||
| + | * '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day. | ||
| + | * '''Day 8:''' stop administration of moclobemide. | ||
| + | | start = | ||
| + | * '''Day 8-9:''' a wash-out period of two days is necessary. | ||
| + | * '''Day 10:''' start escitalopram after this period in a normal dosage of 10 mg/day. | ||
| + | | info = | ||
| + | * Caution is necessary, because occurrence of the serotonin syndrome is theoretically possible. | ||
| + | }} | ||
Revision as of 23:44, 4 March 2010
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Switch medication from moclobemide to escitalopram.[1] [2]
Stop moclobemide - Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
- Day 1: reduce the dosage of moclobemide to 150 mg/day.
- Day 8: stop administration of moclobemide.
Start escitalopram- Day 8-9: a wash-out period of two days is necessary.
- Day 10: start escitalopram after this period in a normal dosage of 10 mg/day.
More information- Caution is necessary, because occurrence of the serotonin syndrome is theoretically possible.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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