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| to = agomelatine
| stop =
* '''Before day 01:''' gradually reduce dosage of mianserine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
* '''Day 1:''' reduce dosage of mianserine to 30 mg/day.
* '''Day 8:''' stop administration of mianserine.
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. <ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>}}