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* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
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* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
