Difference between revisions of "Combining-Lamotrigine-Topiramate"
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| − | | base = | + | | base = lamotrigine |
| − | | add = | + | | add = topiramate |
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| − | * | + | * This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. |
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| start = | | start = | ||
| − | * Topiramate does not cause a significant change in lamotrigine levels | + | * Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice. |
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Adding topiramate to lamotrigine.
General information- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start topiramate- Topiramate does not cause a significant change in lamotrigine levels. [4] Start topiramate according to the general dosing advice.
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ 2.0 2.1 2.2 Farmacotherapeutisch Kompas - lamotrigine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content Cite error: Invalid<ref>tag; name "ftk" defined multiple times with different content - ↑ Drugs.com lamotrigine
- ↑ Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23
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