Difference between revisions of "Combining-Lithium-Risperidone"
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* Risperidone is principally metabolized by CYP2D6 to an active metabolite. | * Risperidone is principally metabolized by CYP2D6 to an active metabolite. | ||
| − | * | + | * This combination may have additive side effects<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>. |
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Adding risperidone to lithium.
General information- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination may have additive side effects[5].
Start risperidone- Start risperidone according to the general dosing advice.
Cave- The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.
- ↑ Farmacotherapeutisch Kompas - lithium (dutch)
- ↑ 2.0 2.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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