Difference between revisions of "Combining-Carbamazepine-Risperidone"
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{{Drugcombi | {{Drugcombi | ||
| − | | base = | + | | base = carbamazepine |
| − | | add = | + | | add = risperidone |
| info = | | info = | ||
| − | * | + | * |
| − | |||
| start = | | start = | ||
| − | * | + | * Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone. |
| + | * Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom"> | ||
| + | {{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref> | ||
| cave = | | cave = | ||
| + | * Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref> | ||
}} | }} | ||
Latest revision as of 10:58, 8 June 2010
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Adding risperidone to carbamazepine.
General information- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
Start risperidone- Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
- Risperidone should be given at higher dosage to control psychotic symptoms. [7]
Cave- Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. [8]
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
- ↑ 4.0 4.1 4.2 KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 6.0 6.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Interactions between risperidone and carbamazepine on drugs.com
- ↑ Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8
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