Difference between revisions of "Combining-Quetiapine-Aripiprazole"
From Psychiatrienet
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* Start aripiprazole according to the general dosing advice. | * Start aripiprazole according to the general dosing advice. | ||
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| − | * Agents with anticholinergic properties may have additive effects when used in combination. | + | * Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom"> |
| + | {{Drugscominteract|quetiapine-with-aripiprazole-233-0-1979-0|quetiapine|aripiprazole}}</ref> | ||
}} | }} | ||
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Adding aripiprazole to quetiapine.
General information- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- There is no evidence published related to this drug combination recently. The combination will have additive side effects.
Start aripiprazole- Start aripiprazole according to the general dosing advice.
Cave- Agents with anticholinergic properties may have additive effects when used in combination. [4]
- ↑ 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content
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