Difference between revisions of "Combining-Olanzapine-Risperidone"
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Adding risperidone to olanzapine.
General information- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
Start risperidone- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Cave- Agents with anticholinergic properties may have additive effects when used in combination. [6]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 5.0 5.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Interactions between risperidone and olanzapine on drugs.com
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