Difference between revisions of "Trazodone-tranylcypromine"
From Psychiatrienet
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| stop = | | stop = | ||
* '''Before day 1:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day. | * '''Before day 1:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day. | ||
| − | * '''Day 1:''' reduce dosage of trazodone to | + | * '''Day 1:''' reduce dosage of trazodone to 100 mg/day. |
| + | * '''Day 3:''' reduce dosage of trazodone to 50 mg/day. | ||
* '''Day 8:''' stop administration of trazodone. | * '''Day 8:''' stop administration of trazodone. | ||
| start = | | start = | ||
| − | * '''Day 8- | + | * '''Day 8-10:''' a wash-out period of 3 days is necessary. |
| − | * '''Day | + | * '''Day 11:''' start administration of tranylcypromine in a dosage of 20 mg/day. |
* If necessary, increase dosage of tranylcypromine. | * If necessary, increase dosage of tranylcypromine. | ||
| info = | | info = | ||
* Occurrence of the serotonin syndrome is theoretically possible, so care is needed. | * Occurrence of the serotonin syndrome is theoretically possible, so care is needed. | ||
* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }} | * The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }} | ||
Revision as of 12:39, 9 January 2012
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Switch medication from trazodone to tranylcypromine.[1] [2]
Stop trazodone - Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 100 mg/day.
- Day 3: reduce dosage of trazodone to 50 mg/day.
- Day 8: stop administration of trazodone.
Start tranylcypromine- Day 8-10: a wash-out period of 3 days is necessary.
- Day 11: start administration of tranylcypromine in a dosage of 20 mg/day.
- If necessary, increase dosage of tranylcypromine.
More information- Occurrence of the serotonin syndrome is theoretically possible, so care is needed.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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