Difference between revisions of "Ziprasidone-Olanzapine LA"
From Psychiatrienet
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| from = Ziprasidone | | from = Ziprasidone | ||
| to = Olanzapine_LA | | to = Olanzapine_LA | ||
| − | | stop = {{ | + | | stop = {{StopStand}} |
| − | | start = {{StartDepot}} | + | | start = {{StartDepot-no-dot}} |
| − | | info = {{caveQT}}{{ | + | | info = {{caveQT}} |
| − | | view = | + | | caveat = |
| + | * {{olanzapine-oral}} | ||
| + | | view = stoporalstartdepot.jpg | ||
}} | }} | ||
Latest revision as of 16:00, 28 January 2013
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Switch medication from Ziprasidone to Olanzapine_LA.[1] [2]
Stop Ziprasidone - Day 1-4: approx. 75% of initial dose
- Day 5-8: approx. 50% of initial dose
- Day 9-12: approx. 25% of initial dose
- Day 13: stop
Start Olanzapine_LA- Day 1: Start depot according general dosing advice
Cave- It is safer first to switch to oral olanzapine and afterwards to olanzapine pamoate. See Switchtable
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
— Ziprasidone — Olanzapine_LA
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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