Difference between revisions of "Bupropion-doxepine"
From Psychiatrienet
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{{Drugswitch | {{Drugswitch | ||
| from = bupropion | | from = bupropion | ||
| − | | to = | + | | to = doxepine |
| stop = | | stop = | ||
{{StopBupropion}} | {{StopBupropion}} | ||
Revision as of 10:57, 21 October 2015
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Switch medication from bupropion to doxepine.[2] [3]
Stop bupropion - Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[4]
Start doxepine- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
More information- Bupropion slows the metabolism of doxepin via CYP2D6.
- Caution is necessary at the start of administration of doxepin.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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