Difference between revisions of "Citalopram-agomelatine"
From Psychiatrienet
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| − | * '''Day | + | * '''Day 16:''' start administration of agomelatine in a dosage of 25 mg/day. |
| − | * '''Day | + | * '''Day 23:''' if necessary, increase dosage of agomelatine to 50 mg/day. |
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref> | <ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref> | ||
Revision as of 13:27, 21 October 2015
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Switch medication from citalopram to agomelatine.[1] [2]
Stop citalopram - Day 1: reduce dosage of citalopram to a maximum of 20 mg/day
- Day 8: reduce dosage of citalopram to 10 mg/day
- Day 15: stop citalopram
Start agomelatine- Day 16: start administration of agomelatine in a dosage of 25 mg/day.
- Day 23: if necessary, increase dosage of agomelatine to 50 mg/day.
More information- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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