Difference between revisions of "Trazodone-citalopram"

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| from = trazodone
 
| from = trazodone
 
| to = citalopram  
 
| to = citalopram  
| stop =  
+
| stop = {{StopSSRI,SNRI}}
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
+
| start = {{StartAntidepressant}}
* '''Day 1:''' reduce dosage of trazodone to 75-100 mg/day.
+
| info =
* '''Day 8:''' stop administration of trazodone.
+
* Safe target dose citalopram = 20 mg
| start =  
+
* {{theorSS}}
* A wash-out period is not necessary, but care is needed.
+
}}
* '''Day 8:''' start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
 
| info =
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes trazodone.
 
* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.  }}
 

Latest revision as of 16:38, 24 February 2023

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from trazodone to citalopram.[1] [2]

Nietinrijdenbord.png Stop trazodone
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start citalopram
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose citalopram = 20 mg
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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