Difference between revisions of "Imipramine-citalopram"

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| to = citalopram  
 
| to = citalopram  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
+
| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
+
| info =
* '''Day 8:''' stop administration of imipramine.
+
* Safe target dose citalopram = 20 mg
| start =  
 
* '''Day 1:''' simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
 
| info =  
 
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes imipramine. 
 
* {{theorSS}}
 
{{review}}
 
 
}}
 
}}

Latest revision as of 11:25, 30 June 2023

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from imipramine to citalopram.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start citalopram
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose citalopram = 20 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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