Difference between revisions of "Nortriptyline-trazodone"

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(Created page with '{{Drugswitch | from = nortriptyline | to = trazodone | stop = * '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/ day, when this dosage is >...')
 
 
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| to = trazodone  
 
| to = trazodone  
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of nortriptyline to 25 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 8:''' stop administration of nortriptyline.
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| info =
| start =  
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* Safe target dose trazodone = 150 mg
No wash-out period is needed.
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}}
* '''Day 1:''' simultaneously start administration of trazodone in a dosage of 150 mg/day.
 
* '''Day 8:''' continue only administration of trazodone. If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
 
| info =
 
* Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.}}
 

Latest revision as of 11:53, 30 June 2023

Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from nortriptyline to trazodone.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start trazodone
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose trazodone = 150 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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