* '''Day 1-3:''' start administration of nortriptyline in a low dosage of 25 mg/day.* '''Day 48:''' increase nortriptyline to a dosage of nortriptyline to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient. 

* Bupropion slows the metabolism of nortriptyline by via CYP2D6.* Caution is necessary at the start of administration of nortriptyline. {{RiskSeizureBupropionTCA}}* {{TCAplasmalevelmonitoring}}}}