* No wash-out period is needed. * Start '''Day 1:''' start paroxetine the next day in low dosage of 10 mg/day.* '''Day 8:''' If necessary, gradually increase dosage| info = * By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. * Bupropion slows the metabolismof paroxetine by CYP2D6.}}