Difference between revisions of "Dosulepine-fluoxetine"
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* '''Day 6 and after''': At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose. | * '''Day 6 and after''': At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose. | ||
+ | * ''' After 3 weeks:''' If necessary, gradually increase dosage of fluoxetine. | ||
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+ | * Safe target dose fluoxetine = 20 mg | ||
* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolize dosulepine. | * Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolize dosulepine. | ||
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Latest revision as of 12:18, 8 March 2024
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Switch medication from dosulepine to fluoxetine.[1] [2]
- Day 1: Decrease with about 25% of the original dose per 3 days.
- Day 6 and after: At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose.
- After 3 weeks: If necessary, gradually increase dosage of fluoxetine.
- Safe target dose fluoxetine = 20 mg
- Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolize dosulepine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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