Difference between revisions of "Amitriptyline-clomipramine"
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| − | | | + | | from = amitriptyline |
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| − | + | {{TCAdecrease25p3d}} | |
| − | + | | start = | |
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* No wash-out period is needed. | * No wash-out period is needed. | ||
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| + | | info = | ||
| + | * {{TCAantichol}} | ||
| + | {{TCAplasmalevelmonitoring}} | ||
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Latest revision as of 11:21, 16 June 2016
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Switch medication from amitriptyline to clomipramine.[1] [2]
Stop amitriptyline - Day 1: Decrease with about 25% of the original dose per 3 days.
Start clomipramine- No wash-out period is needed.
- Day 1: Increase with about 25% of target dose per 3 days.
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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