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Difference between revisions of "Clomipramine-tranylcypromine"

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| to = tranylcypromine  
 
| to = tranylcypromine  
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
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{{TCAdecrease25p3d}}
* '''Day 1-7:''' reduce dosage of clomipramine to 37,5 mg/day.
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*Stop and wait 10 days for washout
* '''Day 8:''' stop administration of clomipramine.
 
 
| start =  
 
| start =  
* '''Day 8-14:''' a wash-out period of one week is necessary.
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*a wash-out period of 10 days is necessary.
* '''Day 15:''' start administration of tranylcypromine in a normal dosage of 20 mg/day.}}
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{{Starttranyl}}
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| caveat =
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{{caveSS}}
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Latest revision as of 12:21, 8 March 2024

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from clomipramine to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
  • Stop and wait 10 days for washout
Eenrichtingbord.png Start tranylcypromine
  • a wash-out period of 10 days is necessary.
  • Start tranylcypromine in a low dosage of 20 mg/day for one week.
  • After this week the dosage of tranylcypromine can be increased.
Letopbord.png Cave


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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