Difference between revisions of "Bupropion-clomipramine"
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− | | start = | + | * '''Day 1:''' start administration of clomipramine in a low dosage of 37,5mg/day. |
− | * '''Day 1 | + | * '''Day 8:''' increase dosage of clomipramine to a dosage of 75 mg/day. |
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* Bupropion slows the metabolism of clomipramine via CYP2D6. | * Bupropion slows the metabolism of clomipramine via CYP2D6. | ||
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* {{RiskSeizureBupropionTCA}} | * {{RiskSeizureBupropionTCA}} | ||
+ | * {{TCAplasmalevelmonitoring}} | ||
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Latest revision as of 10:55, 4 August 2023
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Switch medication from bupropion to clomipramine.[1] [2]
- Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
- Day 1: start administration of clomipramine in a low dosage of 37,5mg/day.
- Day 8: increase dosage of clomipramine to a dosage of 75 mg/day.
- Bupropion slows the metabolism of clomipramine via CYP2D6.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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