Difference between revisions of "Bupropion-clomipramine"
| (3 intermediate revisions by 2 users not shown) | |||
| Line 3: | Line 3: | ||
| to = clomipramine | | to = clomipramine | ||
| stop = | | stop = | ||
| − | + | {{stopBupropion}} | |
| − | + | | start = | |
| − | | start = | + | * '''Day 1:''' start administration of clomipramine in a low dosage of 37,5mg/day. |
| − | * '''Day 1 | + | * '''Day 8:''' increase dosage of clomipramine to a dosage of 75 mg/day. |
| − | * '''Day | ||
| info = | | info = | ||
* Bupropion slows the metabolism of clomipramine via CYP2D6. | * Bupropion slows the metabolism of clomipramine via CYP2D6. | ||
| − | |||
* {{RiskSeizureBupropionTCA}} | * {{RiskSeizureBupropionTCA}} | ||
| + | * {{TCAplasmalevelmonitoring}} | ||
}} | }} | ||
Latest revision as of 10:55, 4 August 2023
| ||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
Switch medication from bupropion to clomipramine.[1] [2]
Stop bupropion - Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start clomipramine- Day 1: start administration of clomipramine in a low dosage of 37,5mg/day.
- Day 8: increase dosage of clomipramine to a dosage of 75 mg/day.
More information- Bupropion slows the metabolism of clomipramine via CYP2D6.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
- ↑ (dutch) monografie.org tricyclische-antidepressiva
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.