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Difference between revisions of "Bupropion-vortioxetine"

 
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| to = vortioxetine  
 
| to = vortioxetine  
 
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| stop =  
* '''Before day 8:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
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{{StopBupropion}}
* '''Day 8:''' When a dosage of 150 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
{{washout8-14}}
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* ''' Day 1: ''' Start vortioxetine with a dosage of 5 mg/day.
* '''Day 14:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
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* ''' Day 8: ''' increase dosage of vortioxetine to a dosage of 10 mg/day.
 
| info =   
 
| info =   
* Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually.
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* Bupropion slows the metabolism of vortioxetine via CYP2D6
 
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Latest revision as of 11:48, 4 August 2023

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from bupropion to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Day 1: Stop bupropion.
  • bupropion can be stopped abruptly for every dosage.[3]
Eenrichtingbord.png Start vortioxetine
  • Day 1: Start vortioxetine with a dosage of 5 mg/day.
  • Day 8: increase dosage of vortioxetine to a dosage of 10 mg/day.
Infobord.png More information
  • Bupropion slows the metabolism of vortioxetine via CYP2D6
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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