Difference between revisions of "Aripiprazole LA-Clozapine"
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Latest revision as of 09:29, 21 April 2023
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Switch medication from Aripiprazole LA to Clozapine.[1] [2]
Stop Aripiprazole LA - Day 1: Last depot injection
Start Clozapine- Day 1: start with 12,5 mg at night
- Day 2: 25 mg in divided doses
- Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
- Day 16-28: if necessary, increase dose with 50-100 mg/week
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
More information- More information you'll find in the summary of product characteristics (SPC) of aripiprazole depot injection. [3]
— Aripiprazole LA — Clozapine
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002755/WC500156111.pdf SPC of the European Medicines Agency on aripiprazole depot
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