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Difference between revisions of "Aripiprazole LA-Clozapine"

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Latest revision as of 09:29, 21 April 2023

Aripiprazole
long acting
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
Medscape Aripiprazole
EMEA abilify
PubChem 60975
PubMed Aripiprazole
Kompas (Dutch) Aripiprazole
Wikipedia Aripiprazole
Clozapine
Type Antipsychotic
Group Atypical AP
links
Medscape Clozapine
PubChem 2818
PubMed Clozapine
Kompas (Dutch) Clozapine
Wikipedia Clozapine

Switch medication from Aripiprazole LA to Clozapine.[1] [2]

Nietinrijdenbord.png Stop Aripiprazole LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Clozapine
  • Day 1: start with 12,5 mg at night
  • Day 2: 25 mg in divided doses
  • Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
  • Day 16-28: if necessary, increase dose with 50-100 mg/week
  • Low dose in the morning, high dose at night (twice daily dosage)
  • Increments are dependent on the status of patient
Infobord.png More information
  • More information you'll find in the summary of product characteristics (SPC) of aripiprazole depot injection. [3]
    StopDepotStartOral.jpg
Nietinrijdenbord.png — Aripiprazole LA
Eenrichtingbord.png — Clozapine


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002755/WC500156111.pdf SPC of the European Medicines Agency on aripiprazole depot
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