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Difference between revisions of "Venlafaxine-duloxetine"

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| to = duloxetine  
 
| to = duloxetine  
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| stop = {{StopSSRI,SNRI}}
* Gradually reduce dosage of duloxetine to a maximum of 75 mg/day.
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| start = {{StartAntidepressant}}
* When a dosage of 75 mg/day is reached, stop administration.
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| start =  
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* Safe target dose duloxetine = 60 mg
* No wash-out period is needed.
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* {{theorSS}}
* Start duloxetine the next day in a normal dosage of 60 mg/day.}}
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Latest revision as of 16:44, 24 February 2023

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from venlafaxine to duloxetine.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start duloxetine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose duloxetine = 60 mg
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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