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Difference between revisions of "Bupropion-fluoxetine"

 
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| to = fluoxetine  
 
| to = fluoxetine  
 
| stop =  
 
| stop =  
{{StopBupropion1}}
+
{{StopBupropion}}
 
| start =  
 
| start =  
*''' Day 2:''' * Start fluoxetine the next day in normal dosage of 20 mg/day.
+
* ''' Day 1: ''' Start fluoxetine with a dosage of 10 mg/day.
* ''' After 3 weeks:''' If necessary, increase the dosage gradually to 40-60 mg/day.
+
* ''' Day 8: ''' If necessary, gradually increase dosage  
 
| info =   
 
| info =   
* No wash-out period is needed.
 
* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
 
* Bupropion slows the metabolism of fluoxetine by CYP2D6.
 
* {{2D6NRI}}
 
 
}}
 
}}

Latest revision as of 11:08, 4 August 2023

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from bupropion to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Day 1: Stop bupropion.
  • bupropion can be stopped abruptly for every dosage.[3]
Eenrichtingbord.png Start fluoxetine
  • Day 1: Start fluoxetine with a dosage of 10 mg/day.
  • Day 8: If necessary, gradually increase dosage


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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