Difference between revisions of "Hypericum-venlafaxine"

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* '''Day 15:''' stop administration of hypericum.
 
* '''Day 15:''' stop administration of hypericum.
 
| start =   
 
| start =   
* '''Day 15-30:''' a wash-out period of at least two weeks is necessary.  
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* '''Day 15-22:''' a wash-out period of at least one week is necessary.<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration.  Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|venlafaxine}}</ref> 
* '''Day 31:''' start venlafaxine 37,5 mg or 75 mg (slow release)/day.
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* '''Day 23:''' {{startVenla}} Increase the dose with about 25% of the target dose every 3 days.
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| info =  
 
| info =  
* Occurrence of the serotonin syndrome is possible without wash-out period.
 
 
{{HypericumInfo}}
 
{{HypericumInfo}}
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{{caveSS}}
 
}}
 
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Latest revision as of 11:50, 14 October 2015

Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine

Switch medication from hypericum to venlafaxine.[1] [2]

Nietinrijdenbord.png Stop hypericum
  • Day 1-14: Gradually decrease the dosage of hypericum.
  • Day 15: stop administration of hypericum.
Eenrichtingbord.png Start venlafaxine
  • Day 15-22: a wash-out period of at least one week is necessary.[3][4][5][6]
  • Day 23: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day. Increase the dose with about 25% of the target dose every 3 days.
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[7]
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