Difference between revisions of "Clomipramine-mirtazapine"

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* '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 25-50 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of clomipramine to 10 mg/day.
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| info =
| start =  
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* Safe target dose mirtazapine = 15 mg
* '''Day 1:''' simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.
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}}
* '''Day 8:''' stop administration of clomipramine and continue administration of mirtazapine.}}
 

Latest revision as of 11:06, 30 June 2023

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from clomipramine to mirtazapine.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start mirtazapine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose mirtazapine = 15 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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