Difference between revisions of "Dosulepine-amitriptyline"

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{{Drugswitch  
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{{Drugswitch
| from = dosulepine  
+
| from = dosulepine
 
| to = amitriptyline  
 
| to = amitriptyline  
 
| stop =  
 
| stop =  
* Gradually reduce dosage of dosulepine to a maximum of 50 mg/day.
+
{{TCAdecrease25p3d}}
* When a dosage of 50 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* Start administration of amitriptyline the next day in a normal dosage of 50-100 mg/day.
+
{{TCAincrease25p3d}}
 
| info =
 
| info =
 
* {{TCAantichol}}
 
* {{TCAantichol}}
 +
{{TCAplasmalevelmonitoring}}
 
}}
 
}}

Latest revision as of 11:13, 30 June 2023

dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from dosulepine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start amitriptyline
  • No wash-out period is needed.
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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