Difference between revisions of "Fluoxetine-maprotiline"
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Caution is necessary for at least four weeks. | Caution is necessary for at least four weeks. | ||
| − | * '''Day | + | * '''Day 2:''' start administration of maprotiline in a low dosage of 25 mg/day. |
| − | * '''Day | + | * '''Day 15:''' increase dosage of maprotiline to 50 mg/day. |
| − | * '''Day | + | * '''Day 29:''' gradually increase dosage of maprotiline to 75 mg/day and more. |
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| − | * Fluoxetine | + | * Fluoxetine and norfluoxetine slow the metabolism of maprotiline via CYP2D6. |
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* Start low, go slow for maprotiline.}} | * Start low, go slow for maprotiline.}} | ||
Latest revision as of 13:54, 28 October 2015
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Switch medication from fluoxetine to maprotiline.[1] [2]
Stop fluoxetine - Reduce the dosage to 20mg/day and then stop the administration
Start maprotilineCaution is necessary for at least four weeks.
- Day 2: start administration of maprotiline in a low dosage of 25 mg/day.
- Day 15: increase dosage of maprotiline to 50 mg/day.
- Day 29: gradually increase dosage of maprotiline to 75 mg/day and more.
More information- Fluoxetine and norfluoxetine slow the metabolism of maprotiline via CYP2D6.
- Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
- Start low, go slow for maprotiline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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