Difference between revisions of "Agomelatine-doxepine"
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Switch medication from agomelatine to doxepine.[2] [3]
Stop agomelatine - Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.[4]
Start doxepine- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
More information- A wash-out period is not necessary.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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