Difference between revisions of "Fluoxetine-venlafaxine"
From Psychiatrienet
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No wash-out period is needed. | No wash-out period is needed. | ||
| − | * '''Day | + | * '''Day 2:''' start venlafaxine the next day in low dosage of 37,5 mg/day. |
| − | * '''Day | + | * '''Day 22:''' increase dosage of venlafaxine to normal, 75 mg/day. |
| + | * '''Day 29:''' gradually increase dosage of venlafaxine, if necessary. | ||
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| − | * Fluoxetine | + | {{longt1/2fluvox}} |
| + | * {{theorSS}} | ||
| + | * Fluoxetine and norfluoxetine inhibit the metabolism of venlafaxine via CYP2D6. | ||
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Latest revision as of 14:40, 28 October 2015
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Switch medication from fluoxetine to venlafaxine.[1] [2]
Stop fluoxetine - Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
- Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Start venlafaxineNo wash-out period is needed.
- Day 2: start venlafaxine the next day in low dosage of 37,5 mg/day.
- Day 22: increase dosage of venlafaxine to normal, 75 mg/day.
- Day 29: gradually increase dosage of venlafaxine, if necessary.
More information- Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine and norfluoxetine inhibit the metabolism of venlafaxine via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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