Difference between revisions of "Duloxetine-fluvoxamine"
From Psychiatrienet
(Created page with '{{Drugswitch | from = duloxetine | to = fluvoxamine | stop = * Gradually reduce dosage of duloxetine to a maximum of 60 mg/day. * When a dosage of 60 mg/day is reached, stop...') |
|||
| (4 intermediate revisions by 4 users not shown) | |||
| Line 3: | Line 3: | ||
| to = fluvoxamine | | to = fluvoxamine | ||
| stop = | | stop = | ||
| − | * | + | {{stopDuloxetine}} |
| − | * | + | | start = |
| − | | | + | * '''Day 11:''' start fluvoxamine 50 mg. |
| − | * | + | * '''Day 15:''' increase administration of fluvoxamine. |
| − | * | + | | info = |
| + | * {{Inhibit1A2FluvoxamineDuloxetine}} | ||
| + | * {{theorSS}} | ||
| + | }} | ||
Latest revision as of 12:20, 4 November 2015
| ||||||||||||||||||||||
| ||||||||||||||||||||||
Switch medication from duloxetine to fluvoxamine.[1] [2]
Stop duloxetine - Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
- Day 8: stop administration of duloxetine.
Start fluvoxamine- Day 11: start fluvoxamine 50 mg.
- Day 15: increase administration of fluvoxamine.
More information- Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2.[3]
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Lobo et al. In vitro and in vivo evaluations of cytochrome P450 1A2 interactions with duloxetine. Clin Pharmacokinet. 2008;47(3):191-202
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
