Difference between revisions of "Agomelatine-trazodone"
From Psychiatrienet
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| − | *'''Day 2:''' Start administration of trazodone the next day in a | + | *'''Day 2:''' Start administration of trazodone the next day in a dosage of 150 mg/day. |
| + | * Increase the dose with about 25% of the target dose every 3 days | ||
|info = | |info = | ||
* No wash-out period is necessary. | * No wash-out period is necessary. | ||
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Latest revision as of 12:04, 14 October 2015
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Switch medication from agomelatine to trazodone.[1] [2]
Stop agomelatine - Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.[3]
Start trazodone- Day 2: Start administration of trazodone the next day in a dosage of 150 mg/day.
- Increase the dose with about 25% of the target dose every 3 days
More information- No wash-out period is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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