Difference between revisions of "Nortriptyline-maprotiline"

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{{Drugswitch  
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{{Drugswitch
 
| from = nortriptyline
 
| from = nortriptyline
 
| to = maprotiline
 
| to = maprotiline
 
| stop =  
 
| stop =  
{{downNortriptyline}}
+
{{TCAdecrease25p3d}}
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* ''' Day 9: ''' start administration of maprotiline in a normal dosage of 25-75 mg/day.
+
{{TCAincrease25p3d}}
 
| info =
 
| info =
* Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
+
{{TCAplasmalevelmonitoring}}
* Actually maprotiline is a TCA with a carbon bridge, so it is also called TetraCyclicAntidepressant.
 
 
}}
 
}}

Latest revision as of 13:39, 30 June 2023

Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from nortriptyline to maprotiline.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start maprotiline
  • No wash-out period is needed.
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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