Difference between revisions of "Vortioxetine-paroxetine"
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| − | * '''Day | + | * '''Day 15:''' start administration of paroxetine in a normal dosage of 10-20 mg/day. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> |
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* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }} | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }} | ||
Latest revision as of 15:15, 4 November 2015
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Switch medication from vortioxetine to paroxetine.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start paroxetine- Day 8-14: a wash-out period of 1 week is necessary.
- Day 15: start administration of paroxetine in a normal dosage of 10-20 mg/day. [3] [4]
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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