Difference between revisions of "Clozapine-Penfluridol"
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| − | | stop = {{ | + | | stop = {{Stopantichol}} |
| info = {{caveQT}} | | info = {{caveQT}} | ||
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Latest revision as of 16:18, 18 March 2022
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Switch medication from Clozapine to Penfluridol.[1] [2]
Stop Clozapine - Week 1: approx. 75% of initial dose
- Week 2: approx. 50% of initial dose
- Week 3: approx. 25% of initial dose
- Week 4: approx. 12,5% of initial dose
- Day 28: stop
Start Penfluridol- Week 1: start with 10 mg
- Week 2: increase dose to 20 mg
- Week 3 and further: adjust dose according to clinical presentation
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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