Difference between revisions of "Tranylcypromine-agomelatine"
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| − | + | {{Tcrestore}}<ref name="informatorium">{{KNMP|tranylcypromine}}</ref> | |
| − | {{Tcrestore}}<ref name="informatorium">{{KNMP|tranylcypromine}}</ref> | + | * Tranylcypromine has to be phased out to avoid withdrawal symptoms.<ref>Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers</ref> |
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Latest revision as of 14:41, 4 August 2023
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Switch medication from tranylcypromine to agomelatine.[1] [2]
Stop tranylcypromine - Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[3]
- If necessary, increase dosage of agomelatine to 50 mg/day.
More information- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[4]
- Tranylcypromine has to be phased out to avoid withdrawal symptoms.[5]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
- ↑ Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers
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