Difference between revisions of "Paroxetine-agomelatine"
From Psychiatrienet
(Created page with '{{ Drugswitch | from = paroxetine | to = agomelatine | stop = * '''Before day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day, when this dosage is > 20 ...') |
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| to = agomelatine | | to = agomelatine | ||
| stop = | | stop = | ||
| − | * '''Before day 0:''' gradually reduce dosage of paroxetine to a maximum of | + | * '''Before day 0:''' gradually reduce dosage of paroxetine to a maximum of 40 mg/day, when this dosage is > 40 mg/day. |
| − | * '''Day | + | * '''Day 1:''' reduce dosage of paroxetine to 20 mg/day. |
| − | * '''Day | + | * '''Day 8:''' reduce dosage of paroxetine to 10 mg/day. |
| + | * '''Day 15:''' stop administration of paroxetine. | ||
| start = | | start = | ||
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. | * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. | ||
| − | * '''Day | + | * '''Day 15:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }} |
Revision as of 08:46, 7 May 2009
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Switch medication from paroxetine to agomelatine.[1] [2]
Stop paroxetine - Before day 0: gradually reduce dosage of paroxetine to a maximum of 40 mg/day, when this dosage is > 40 mg/day.
- Day 1: reduce dosage of paroxetine to 20 mg/day.
- Day 8: reduce dosage of paroxetine to 10 mg/day.
- Day 15: stop administration of paroxetine.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 15: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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