Difference between revisions of "Fluoxetine-trazodone"
From Psychiatrienet
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* '''Before day 1:'''gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. | * '''Before day 1:'''gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. | ||
| − | * ''' | + | * '''Day 1:'''When a dosage of 20 mg/day is reached, stop administration. |
| start = | | start = | ||
| − | * | + | * '''Day 1-21:''' A wash-out period is needed. |
| − | * Start trazodone | + | * '''Day 22:'''Start trazodone in a dosage of 100-150 mg/day. |
| − | * If necessary, increase the dosage of trazodone to a maximum of 400 mg/day. | + | * '''After day 28 :'''If necessary, increase gradually the dosage of trazodone to a maximum of 400 mg/day. |
| info = | | info = | ||
* Fluoxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary for at least four weeks.}} | * Fluoxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary for at least four weeks.}} | ||
| + | * {{therSS}} | ||
| + | }} | ||
Revision as of 16:32, 20 July 2009
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Switch medication from fluoxetine to trazodone.[1] [2]
Stop fluoxetine - Before day 1:gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- Day 1:When a dosage of 20 mg/day is reached, stop administration.
Start trazodone- Day 1-21: A wash-out period is needed.
- Day 22:Start trazodone in a dosage of 100-150 mg/day.
- After day 28 :If necessary, increase gradually the dosage of trazodone to a maximum of 400 mg/day.
More information- Fluoxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary for at least four weeks.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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