Difference between revisions of "Moclobemide-trazodone"
From Psychiatrienet
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| to = trazodone | | to = trazodone | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 300 mg/day. |
* '''Day 1:''' reduce dosage of moclobemide to 150 mg/day. | * '''Day 1:''' reduce dosage of moclobemide to 150 mg/day. | ||
* '''Day 8:''' stop administration of moclobemide. | * '''Day 8:''' stop administration of moclobemide. | ||
Revision as of 15:32, 17 November 2009
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Switch medication from moclobemide to trazodone.[1] [2]
Stop moclobemide - Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
- Day 1: reduce dosage of moclobemide to 150 mg/day.
- Day 8: stop administration of moclobemide.
Start trazodone- Day 8-9: a wash-out period of two days is necessary.
- Day 10: start administration of trazodone in a dosage of 100 mg/day.
- Day 17: if necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
More information- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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