Difference between revisions of "Clomipramine-venlafaxine"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = venlafaxine | | to = venlafaxine | ||
| stop = | | stop = | ||
| − | * '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of | + | * '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day. |
| − | + | * '''Day 1:''' reduce dosage of clomipramine to 25 mg/day. | |
| − | * '''Day | + | * '''Day 8:''' stop administration of clomipramine. |
| − | * '''Day | ||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 8:''' {{startVenla}} |
| − | * '''Day | + | * '''Day 15:''' increase dosage of venlafaxine. |
| info = | | info = | ||
| − | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}} | + | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. |
| + | }} | ||
Revision as of 16:16, 28 July 2009
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Switch medication from clomipramine to venlafaxine.[1] [2]
Stop clomipramine - Before day 0: gradually reduce dosage of clomipramine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop administration of clomipramine.
Start venlafaxine- Day 8: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
- Day 15: increase dosage of venlafaxine.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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