Difference between revisions of "Duloxetine-nortriptyline"
From Psychiatrienet
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* '''Before day 0:''' gradually reduce dosage of bupropion to a maximum of 60 mg/day. | * '''Before day 0:''' gradually reduce dosage of bupropion to a maximum of 60 mg/day. | ||
* '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day. | * '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day. | ||
| + | * '''Day 8:''' stop administration of duloxetine. | ||
| start = | | start = | ||
| − | + | * '''Day 8:''' start administration of nortriptyline in a low dosage of 25 mg/day. | |
| − | * '''Day | + | * '''Day 15:''' increase the dosage of nortriptyline. |
| − | * '''Day | ||
| info = | | info = | ||
* Duloxetine slows the metabolism of nortriptyline by CYP2D6. | * Duloxetine slows the metabolism of nortriptyline by CYP2D6. | ||
}} | }} | ||
Revision as of 08:26, 4 August 2009
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Switch medication from duloxetine to nortriptyline.[1] [2]
Stop duloxetine - Before day 0: gradually reduce dosage of bupropion to a maximum of 60 mg/day.
- Day 1: reduce the dosage of duloxetine to 30 mg/day.
- Day 8: stop administration of duloxetine.
Start nortriptyline- Day 8: start administration of nortriptyline in a low dosage of 25 mg/day.
- Day 15: increase the dosage of nortriptyline.
More information- Duloxetine slows the metabolism of nortriptyline by CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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