Difference between revisions of "Olanzapine LA-Paliperidone LA"

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Revision as of 16:10, 15 February 2010

Olanzapine
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Olanzapine
EMEA zypadhera
PubChem 4585
PubMed Olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone

Switch medication from Olanzapine_LA to Paliperidone_LA.[1] [2]

Nietinrijdenbord.png Stop Olanzapine_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Paliperidone_LA
  • Start depot according to general dosing advice on the day you normally would have injected the former depot.
  • Testing for acceptance and possible allergic reactions in a low dose can be carried out earlier.

Paliperidone palmitate is since spring 2011 approved by EMEA: therefore this switch is under construction.

Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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