Difference between revisions of "Imipramine-citalopram"

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* Citalopram is a weak inhibitor of CYP2D6, which metabolizes imipramine.   
 
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes imipramine.   
 
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* {{theorSS}}
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Revision as of 08:43, 4 November 2015

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from imipramine to citalopram.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
  • Day 1: reduce dosage of imipramine to 50 mg/day.
  • Day 3: reduce dosage of imipramine to 25 mg/day.
  • Day 8: stop administration of imipramine.
Eenrichtingbord.png Start citalopram
  • Day 1: simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
Infobord.png More information
  • Citalopram is a weak inhibitor of CYP2D6, which metabolizes imipramine.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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