Difference between revisions of "Combining-Lithium-Lamotrigine"
From Psychiatrienet
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* This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>. | * This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>. | ||
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Revision as of 11:55, 4 May 2010
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Adding lamotrigine to lithium.
General information- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- This combination of drugs may be rational, but more data is needed.[4].
Start lamotrigine- Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. [5]
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas - lithium (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Drugs.com lamotrigine
- ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- ↑ 10971302 Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5
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