Difference between revisions of "Doxepine-paroxetine"
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| − | * '''Day | + | * '''Day 16''' start administration of paroxetine in a normal dosage of 20 mg/day. |
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* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes doxepin. | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes doxepin. | ||
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Revision as of 13:34, 2 November 2015
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Switch medication from doxepin to paroxetine.[2] [3]
Stop doxepin 
Start paroxetine- Day 16 start administration of paroxetine in a normal dosage of 20 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes doxepin.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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