Difference between revisions of "Amitriptyline-tranylcypromine"
From Psychiatrienet
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* '''Day 8-14:''' a wash-out period of one week is necessary. | * '''Day 8-14:''' a wash-out period of one week is necessary. | ||
| − | * '''Day 15:''' start administration of tranylcypromine in a | + | * '''Day 15:''' start administration of tranylcypromine in a low dosage of 20 mg/day for one week. |
| + | * '''Day 22:''' after this week the dosage of tranylcypromine can be increased if necessary.}} | ||
Revision as of 10:44, 6 May 2009
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Switch medication from amitriptyline to tranylcypromine.[1] [2]
Stop amitriptyline - Before day 0: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
- Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
- Day 8: stop administration of amitriptyline.
Start tranylcypromine- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of tranylcypromine in a low dosage of 20 mg/day for one week.
- Day 22: after this week the dosage of tranylcypromine can be increased if necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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