Difference between revisions of "Vortioxetine-moclobemide"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = moclobemide | | to = moclobemide | ||
| stop = | | stop = | ||
| − | {{stopVortioxetine}} | + | {{stopVortioxetine}} |
| start = | | start = | ||
| − | * '''Day 8-23:''' a wash-out period of 2 weeks is necessary. | + | * '''Day 8-23:''' a wash-out period of 2 weeks is necessary. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> |
* '''Day 24:''' start administration of moclobemide in normal dosage of 300 mg/day. | * '''Day 24:''' start administration of moclobemide in normal dosage of 300 mg/day. | ||
| caveat = {{caveSS}} | | caveat = {{caveSS}} | ||
}} | }} | ||
Revision as of 15:10, 4 November 2015
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Switch medication from vortioxetine to moclobemide.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start moclobemide- Day 8-23: a wash-out period of 2 weeks is necessary. [3] [4]
- Day 24: start administration of moclobemide in normal dosage of 300 mg/day.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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