Difference between revisions of "Vortioxetine-paroxetine"

Revision as of 12:46, 20 February 2025

{{Drugswitch | from = vortioxetine | to = paroxetine | stop =

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Day 7 and after: At approximately 50-25% of the original vortioxetine dose start paroxetine at 50% of the target dose.
Day 14: Increase paroxetine to 100% of the target dose

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 | to = paroxetine
 | stop =
-{{stopVortioxetine}}
+{{TCAdecrease25p3d}}
 | start =
-{{washout8-14}}
+* '''Day 7 and after''': At approximately 50-25% of the original vortioxetine dose start paroxetine at 50% of the target dose.
-* '''Day 15:''' start administration of paroxetine in a normal dosage of 10-20 mg/day. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
+* '''Day 14:''' Increase paroxetine to 100% of the target dose
 | info =
-* {{theorSS}}
+* Safe target dose paroxetine = 20 mg
-* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}
+* paroxetine is a strong CYP2D6 inhibitor, which metabolize vortioxetine.