Difference between revisions of "Imipramine-trazodone"
From Psychiatrienet
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No wash-out period is needed. | No wash-out period is needed. | ||
* '''Day 4:''' simultaneously start administration of trazodone in a dosage of 150 mg/day. | * '''Day 4:''' simultaneously start administration of trazodone in a dosage of 150 mg/day. | ||
| − | * '''Day 8:''' continue | + | * '''Day 8:''' continue administration of trazodone. {{upTrazo}} |
| − | |||
| info = | | info = | ||
* Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.}} | * Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.}} | ||
Revision as of 20:03, 30 July 2009
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Switch medication from imipramine to trazodone.[1] [2]
Stop imipramine - Before day 0: gradually reduce dosage of imipramine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of imipramine to 25 mg/day.
- Day 8: stop administration of imipramine.
Start trazodoneNo wash-out period is needed.
- Day 4: simultaneously start administration of trazodone in a dosage of 150 mg/day.
- Day 8: continue administration of trazodone. If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
More information- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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